E-cigarette or vaping product use-associated lung injury (EVALI) was first reported in 2019–2020 in the USA. Electronic cigarettes (ECs) are commonly used by youth and young adults with a rapidly increasing number of users. Appropriate levels of TRAIL may be important to control IAV infection in EC users.Ĭigarette smoking is a well-recognized risk factor for various lung pathologies including chronic obstructive pulmonary disease (COPD), respiratory infections, asthma, and lung cancer. Our results suggest that EC exposure in human distal lungs amplifies viral infection and TRAIL release, and that TRAIL may serve as a mechanism to regulate viral infection. Further, recombinant TRAIL enhanced the expression of interferon-β and interferon-λ induced by E-juice exposure in IAV-infected PCLS. Conversely, recombinant TRAIL decreased tissue viral load but increased viral release into supernatants. TRAIL neutralizing antibody increased tissue viral load but reduced viral release into supernatants. E-juice increased viral load, TRAIL, TNF-α release and cytotoxicity in IAV-infected PCLS. TRAIL neutralizing antibody and recombinant TRAIL were utilized to determine the contribution of TRAIL to viral infection during EC exposures.
PCLS prepared from lungs of nonsmoker healthy human donors were exposed to EC juice (E-juice) and IAV for up to 3 days during which viral load, TRAIL, lactate dehydrogenase (LDH), and TNF-α in the tissue and supernatants were determined. This study was aimed to investigate the effect of ECs on viral infection and TRAIL release in a human lung precision-cut lung slices (PCLS) model, and the role of TRAIL in regulating IAV infection. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a protein of the TNF family involved in cell apoptosis, is upregulated in COPD patients and during influenza A virus (IAV) infections, but its role in viral infection during EC exposures remains unclear. CreditsĪ very special thanks to the all the developers of our beloved dependencies, and to svg2android for providing the inspiration and source of the Vector Drawable converter.The use of electronic nicotine dispensing systems (ENDS), also known as electronic cigarettes (ECs), is common among adolescents and young adults with limited knowledge about the detrimental effects on lung health such as respiratory viral infections and underlying mechanisms. Please have a look at our contribution guidelines. The options are the same as the convert()-equivalent. swift file with each input svg as separate variables.Īnd the other formats output one output file per input file. The number of files in the outputs-array depends on the format.Ĭurrently the swift-based formats, cashapelayer and uibezierpath, compressed - whether the output should have its whitespace stripped.
codeIndent - a string of whitespace to be used for indentation.Svgsus.svg(svg, options).then(cleanedSvg => fs.writeFileSync('example-cleaned.svg')) const fs = require('fs')Ĭonst svg = fs.readFileSync('example.svg', 'utf8') It reads a an SVG fileĪnd generates a cleaned version of it. Svgsus exports a few converters which each take an SVG and (an optional)Ī quick example to demonstrate using svgsus as a library. The formatted output will be piped to stdout. If no files are specified svgsus expects an SVG to be piped in using stdin and output= a directory to write converted files to, defaults to codeType= must be either "AppKit" or "UIKit" compressed whether the output should have whitespace stripped name= the id of the symbol in the sheet stripStyle whether to remove any style tags from the SVG so it's
Usage Command Line Svgsus - Organize, clean and transform your SVGs Read all about them on our website and our medium post. The app, besides providing a GUI for this tool, also has a few more features.
Svgsus github windows#
(versions for Windows and Linux are planned). There's also the option of installing Svgsus as an App if you're on macOS Keep it local to your project to make it easier for your fellow developers. Or if you want to use svgsus as a library in your project you also use npm but To use svgsus as a command line tool anywhere in your system you simply need
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